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Avenanthramide and Saponin Bioavailability in Oat Bran

NCT04335435 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 13

Last updated 2020-08-06

No results posted yet for this study

Summary

Avenanthramides and saponins are types of chemical compounds found naturally in oats.

Avenanthramides have anti-oxidant properties, anti-atherosclerotic, anti-inflammation, and anti-proliferative effects on cancer cells in vitro. Oat saponins, or avenacosides, have the ability to bind cholesterol, and thus, the ability to lower blood cholesterol.

Oat bran is a known source of these dietary compounds. This study aims to determine the bioavailability of these compounds to in the urine of participants after ingesting an oat bran cereal, both before, and after for multiple time points.

Analytical chemistry will be used to determine the bioavailability of the oat compounds at each time point. This will help to establish a kinetic curve for the metabolism of these compounds.

Conditions

  • Human Health
  • Polyphenols
  • Pharmacokinetics

Interventions

DIETARY_SUPPLEMENT

Oat Bran Consumption

Oat bran (120 g), single dose.

Sponsors & Collaborators

  • North Carolina Agriculture & Technical State University

    lead OTHER

Principal Investigators

  • Shengmin Sang, PhD · North Carolina Agriculture and Technical State University

Study Design

Allocation
NA
Purpose
BASIC_SCIENCE
Masking
NONE
Model
SINGLE_GROUP

Eligibility

Min Age
18 Years
Max Age
50 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2016-01-15
Primary Completion
2016-01-21
Completion
2016-01-21

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04335435 on ClinicalTrials.gov