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Absorption and Excretion Kinetics of the Bioactive Ingredients of Rice Bran Extract

NCT02944084 · Status: COMPLETED · Phase: EARLY_PHASE1 · Type: INTERVENTIONAL · Enrollment: 12

Last updated 2017-05-03

No results posted yet for this study

Summary

The oral absorption and urinary excretion kinetics of the bioactive ingredients from rice bran (gamma-oryzanol, tocotrienols, tocopherols and ferulic acid esters) after incorporation into an oat porridge (oat porridge) compared to unprocessed rice bran extract oil were investigated. The influence of the type of preparation (with water vs. milk) of porridge on the bioavailability of the bioactive compounds was compared. The study followed a single dose (2 g rice bran extract), randomized, three armed crossover study design with ≥1-week washout periods. Plasma and urine samples were collected at intervals up to 24 h after intake.

Conditions

  • Safety After Oral Intake
  • Pharmacokinetics After Oral Intake

Interventions

DIETARY_SUPPLEMENT

Rice bran extract

DIETARY_SUPPLEMENT

Porridge in water

DIETARY_SUPPLEMENT

Porridge in milk

Sponsors & Collaborators

  • German Federal Ministry of Economics and Technology

    collaborator OTHER_GOV

  • University of Hohenheim

    lead OTHER

Principal Investigators

  • Jan Frank, Prof. Dr · University of Hohenheim

Study Design

Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
NONE
Model
CROSSOVER

Eligibility

Min Age
18 Years
Max Age
35 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2016-04-30
Primary Completion
2016-06-30
Completion
2017-04-30

Countries

  • Germany

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT02944084 on ClinicalTrials.gov