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Nitro-oxidative Stress in Periodontitis

NCT02127203 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 80

Last updated 2015-10-05

No results posted yet for this study

Summary

Periodontitis is a chronic inflammatory disease whose etio-pathogencity is not fully understood yet. Reactive oxygen species (ROS) and reactive nitrogen species (RNS) are involved in physiological and pathological processes. Nitro-oxidative stress has been implicated in Periodontitis.

The aim of this study is to assess the levels of ROS and RNS in serum and gingival crevicular fluid (GCF) samples taken from periodontitis (chronic and aggressive) patients and healthy controls. Subsequently, correlating these levels with the severity of periodontal disease.

Eighty subjects will be invited to participate in this study. Patients will be allocated into four groups (20 patients each). The biochemical parameters that will be investigated are Malondialdehyde (MDA) (using TBRSA assay) as a marker of oxidative stress and (NO- level using Griess reagent) as a marker of nitrosative stress.

Conditions

  • Chronic Periodontitis
  • Aggressive Periodontitis

Sponsors & Collaborators

  • Damascus University

    lead OTHER

Principal Investigators

  • Abeer Alasadi, DDS · MSc student, Department of Periodontology, University of Damascus Dental School

  • Ali Abou Sulaiman, DDS MSc Phd · Senior Lecturer in Periodontics, University of Damascus Dental School, Damascus

  • Francoise Qarabit, BSc MSc PhD · Senior Lecturer in Chemistry, Department of Chemistry, Faculty of Sciences, University of Damascus, Baramkeh, Damascus, Syria

Eligibility

Min Age
18 Years
Max Age
60 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2014-05-31
Primary Completion
2015-09-30
Completion
2015-10-31

Countries

  • Syria

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT02127203 on ClinicalTrials.gov