Periodontal Phenotype Study (Tooth Extraction)

Summary

The purpose of this trial is to determine the correlations between various tissue dimensions and the changes that occur following a single-tooth dental extraction in human adults.

65 adult subjects who are in need of dental extractions will be recruited. Clinical measurements will be gathered prior to and immediately following the single tooth extraction. There will be a 2-week post-operative visit to assess healing and a 14-week follow-up for photographic documentation and clinical measurements of the extraction area.

Conditions

• Tooth Extraction Status Nos

Interventions

OTHER

consent

At the initial screening examination, each subject will receive an informed consent form. Prior to signing the informed consent, one of the investigators or qualified staff will thoroughly discuss participation in the study with each subject, allocating time for questions and answers.

OTHER

Screening

At the initial screening examination, complete medical and dental history will be obtained to verify eligibility.

OTHER

Xray

each subject will undergo site-specific oral radiographic exam (new periapical radiographs will be obtained if needed) to evaluate potential study sites.

OTHER

PVS Impressions

PVS impressions of the arch of interest will be obtained in order perform volumetric analysis of the area of interest.

OTHER

Photographs

Intraoral photographs will also be taken and subsequent study visits will be planned.

OTHER

CBCT

The patient will then be sent to the Department of Radiology at the College of Dentistry for a baseline CBCT and follow-up at 14 week CBCT. These CBCT's will be utilized to evaluate the hard tissue volume in comparison to the clinical volume of soft tissue.

OTHER

Anesthesia

After appropriate local anesthetic is administered and anesthesia is achieved, the buccal tissue thickness will be measured and recorded.

PROCEDURE

Extraction

After the pre-extraction baseline measurements are recorded and adequate anesthesia is confirmed, minimally invasive extraction procedures will be initiated. All extractions will be performed by residents in the UI CoD Periodontics advanced education program.

OTHER

Clinical measurements

Measuring soft tissue dimensions, bone thickness prior to and immediately after extraction and then after appropriate healing time frames.

Sponsors & Collaborators

• Gustavo Avila-Ortiz DDS, MS, PhD

  lead OTHER

Principal Investigators

• Gustavo Avila Ortiz, BSE, DDS · University of Iowa

Study Design

Allocation

NA

Purpose

TREATMENT

Masking

NONE

Model

SINGLE_GROUP

Eligibility

Min Age

18 Years

Max Age

75 Years

Sex

ALL

Healthy Volunteers

Yes

Timeline & Regulatory

Start

2016-01-31

Primary Completion

2020-06-15

Completion

2020-06-15

Countries

• United States

Study Locations