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Animal and Plant Proteins and Glucose Metabolism

NCT03994367 · Status: RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 100

Last updated 2026-05-08

No results posted yet for this study

Summary

The goal of this proposal is to determine the effect of a high protein diet in which the increase in protein intake is derived from different sources (animal vs plant and protein-rich whole foods vs protein isolates) on: i) liver and muscle insulin sensitivity; ii) the metabolic response to a meal, and iii) 24-h plasma concentration profiles of glucose, glucoregulatory hormones, and protein-derived metabolites purported to cause metabolic dysfunction.

Conditions

Interventions

OTHER

High animal protein isolate

Increased dietary protein content from animal protein isolates

OTHER

High animal protein whole food

Increased dietary protein content from animal protein whole food

OTHER

High plant protein isolate

Increased dietary protein content from plant protein isolates

OTHER

High plant protein whole food

Increased dietary protein content from animal protein whole food

Sponsors & Collaborators

  • University of Missouri-Columbia

    lead OTHER

Principal Investigators

  • Bettina Mittendorfer · University of Missouri-Columbia

Study Design

Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
SINGLE
Model
PARALLEL

Eligibility

Min Age
21 Years
Max Age
70 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2019-07-12
Primary Completion
2028-02-25
Completion
2028-04-25

Countries

  • United States

Study Locations

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Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03994367 on ClinicalTrials.gov