A Randomised Trial of Expedited Transfer to a Cardiac Arrest Centre for Non-ST Elevation Out-of-hospital Cardiac Arrest

Summary

The aim of ARREST is to determine the best post-resuscitation care pathway for out of hospital cardiac arrest patients without ST-segment elevation. The investigators propose that changes to emergency management comprising expedited delivery to a specialist heart attack centre with organised post-cardiac arrest care including immediate access to reperfusion therapy will reduce mortality in patients without STE compared to the current standard of care, which comprises protracted pre-hospital management of the patient without definitive care plan and delivery to geographically closest hospital.

Conditions

• Out-Of-Hospital Cardiac Arrest

Interventions

PROCEDURE

Transfer to cardiac arrest centre

Patients in the intervention arm will be taken directly to a the catheter lab of a heart attack centre.

Sponsors & Collaborators

• King's College London

  collaborator OTHER

• London School of Hygiene and Tropical Medicine

  collaborator OTHER

• Barts & The London NHS Trust

  collaborator OTHER

• King's College Hospital NHS Trust

  collaborator OTHER

• Imperial College Healthcare NHS Trust

  collaborator OTHER

• Royal Brompton & Harefield NHS Foundation Trust

  collaborator OTHER

• Royal Free Hospital NHS Foundation Trust

  collaborator OTHER

• St George's University Hospitals NHS Foundation Trust

  collaborator OTHER

• London Ambulance Service NHS Trust

  collaborator OTHER

• Guy's and St Thomas' NHS Foundation Trust

  lead OTHER

Principal Investigators

• Simon Redwood, MBBS, PhD · Guy's and St Thomas' NHS Foundation Trust

Study Design

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

TRIPLE

Model

PARALLEL

Eligibility

Min Age

18 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2018-02-02

Primary Completion

2023-12-04

Completion

2024-04-30

Countries

• United Kingdom

Study Locations