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Restricted or Liberal Fluid for Haemodynamic Resuscitation in Sepsis

NCT05453565 · Status: NOT_YET_RECRUITING · Type: OBSERVATIONAL · Enrollment: 7838

Last updated 2025-01-03

No results posted yet for this study

Summary

A prospective, individual patient data meta-analysis (IPDMA) of four multicentre, open-label, randomised clinical trials of initial haemodynamic resuscitation in patients with septic shock.

Conditions

  • Septic Shock
  • Fluid Resuscitation

Interventions

OTHER

Vasopressors

A haemodynamic resuscitation strategy based upon the restriction of IV fluids (by either volume or rate of infusion) with initiation or change of rate of vasopressors if required to meet perfusion targets

OTHER

Fluids

A strategy of resuscitation with intravenous fluids as the primary intervention to achieve perfusion targets with subsequent initiation or change of rate of vasopressors if required.

Sponsors & Collaborators

  • Australian and New Zealand Intensive Care Research Centre

    lead OTHER

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2025-11-30
Primary Completion
2026-11-30
Completion
2026-11-30

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05453565 on ClinicalTrials.gov