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RECOMMEND Platform Trial

NCT06526533 · Status: RECRUITING · Phase: PHASE3 · Type: INTERVENTIONAL · Enrollment: 600

Last updated 2026-05-13

No results posted yet for this study

Summary

The goal of this platform trial is to determine the efficacy, safety and cost-effectiveness of various interventions in patients with acute cardiorespiratory failure requiring extracorporeal membrane oxygenation (ECMO)

The main question the platform trial aims to address is to determine the effect of a range of interventions on survival, organ support and resource utilisation to day 28 for hospitalised patients receiving ECMO.

Researchers will compare various interventions within multiple platform trial domains to see if the interventions have effects on survival, organ support and resource utilisation for the patient cohort.

Participants will be enrolled in accordance with the platform trial's domain structure to answer the research questions.

Conditions

  • Extracorporeal Membrane Oxygenation Complication
  • ARDS (Acute Respiratory Distress Syndrome)
  • Intensive Care Medicine
  • Cardiac Arrest (CA)
  • Critical Illness

Interventions

OTHER

Liberal RBC Transfusion

Liberal transfusion trigger group (patient receives RBC transfusion if Hb \<90g/L).

OTHER

Restrictive RBC Transfusion

Restrictive transfusion trigger group (patient receives RBC transfusion if Hb \<70g/L).

Sponsors & Collaborators

  • Monash University

    collaborator OTHER

  • Berry Consultants

    collaborator OTHER

  • Research Path

    collaborator UNKNOWN

  • Australian and New Zealand Intensive Care Research Centre

    lead OTHER

Principal Investigators

  • Carol Hodgson, PhD FACP FAHMS · Monash University

Study Design

Allocation
RANDOMIZED
Purpose
SUPPORTIVE_CARE
Masking
NONE
Model
SEQUENTIAL

Eligibility

Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2026-03-23
Primary Completion
2028-06-30
Completion
2029-06-30

Countries

  • Australia

Study Locations

More Related Trials

Entities

Companies

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06526533 on ClinicalTrials.gov