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Physiological Effects of 38°C vs. 22°C Fluid Therapy in Critically Ill Patients

NCT04576806 · Status: WITHDRAWN · Phase: NA · Type: INTERVENTIONAL

Last updated 2023-03-10

No results posted yet for this study

Summary

A randomized controlled clinical trial. 24 adult ICU patients will be recruited upon decision to administer fluid bolus of 500ml of crystalloid. The fluid will then be randomized to be infused at controlled room temperature or warmed to body temperature. Hemodynamic measurements will be made for 2 hours following the bolus, and laboratory values will be noted. The hypothesis is that part of the hemodynamic response will differed in response to cooling, and be larger in the cold group.

Conditions

  • Critical Illness
  • Sepsis
  • Fluid Overload
  • Hemodynamic Instability

Interventions

OTHER

Body temperature

Warming of administered fluid bolus

DRUG

Fluid bolus

Administration of fluid bolus of crystalloid of 500ml over 15 minutes

OTHER

Room temperature

Cooling of administered fluid bolus

Sponsors & Collaborators

  • Danderyd Hospital

    collaborator OTHER

  • Stockholm South General Hospital

    collaborator OTHER

  • Karolinska Institutet

    lead OTHER

Principal Investigators

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2021-04-30
Primary Completion
2021-10-30
Completion
2021-10-30

Countries

  • Sweden

Study Locations

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Entities

Diseases
Companies

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04576806 on ClinicalTrials.gov