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Bicarbonate for In-Hospital Cardiac Arrest

NCT05564130 · Status: ACTIVE_NOT_RECRUITING · Phase: PHASE4 · Type: INTERVENTIONAL · Enrollment: 778

Last updated 2026-02-17

No results posted yet for this study

Summary

This is an investigator-initiated, multicenter, randomized, placebo-controlled, parallel group, double-blind, superiority trial of sodium bicarbonate during adult in-hospital cardiac arrest. There will be 22 enrolling sites in Denmark. 778 adult patients with in-hospital cardiac arrest receiving at least one dose of adrenaline will be enrolled. The primary outcome is return of spontaneous circulation and key secondary outcomes include survival at 30 days and survival at 30 days with a favorable neurological outcome.

Conditions

  • Cardiac Arrest

Interventions

DRUG

Sodium bicarbonate

Sodium bicarbonate 1 mmol/ml

DRUG

Sodium chloride

Sodium chloride 9 mg/mL

Sponsors & Collaborators

  • University of Aarhus

    collaborator OTHER

  • Lars Wiuff Andersen

    lead OTHER

Principal Investigators

  • Lars W Andersen · Aarhus University Hospital

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
QUADRUPLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2023-02-06
Primary Completion
2026-02-11
Completion
2027-02-11

Countries

  • Denmark

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05564130 on ClinicalTrials.gov