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DNA Methylation Profile of the SOCS-1 Gene Promoter in Smokers Patients With Chronic Periodontitis.

NCT03371446 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 60

Last updated 2017-12-13

No results posted yet for this study

Summary

Periodontitis is related to host genetics, constitution of the dental biofilm and environmental factors such as smoking. DNA methylation is a mechanism of genetic expression that can inhibit or silence gene expression. In this way several researchers have been dedicated to study the genetic influence on the susceptibility and / or increased risk to periodontal disease. Studies have reported association between several epigenetic biomarkers with periodontal inflammation. Considering the hypothesis that there is an association between smoking and methylation in genes related to periodontal disease, the objective of this study was to verify the DNA methylation pattern in oral epithelial cells of patients with chronic periodontitis (CP) in the promoter of a specific gene involved in the control of inflammation, as suppressor of cytokine signaling (SOCS) 1 in smokers and nonsmokers patients.

Conditions

  • Periodontal Diseases
  • Epigenetics

Interventions

GENETIC

oral epithelial cells obtained by rinsing with 3% sucrose

rinsing with 3% sucrose, for a single time of collection, patients received periodontal treatment after collection and data analysis.

Sponsors & Collaborators

  • University of Sao Paulo

    lead OTHER

Principal Investigators

  • Arthur B. Novaes Junior, DDS, PhD · Study Principal Investigator

Eligibility

Min Age
30 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2016-06-06
Primary Completion
2017-10-16
Completion
2017-11-18

Countries

  • Brazil

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03371446 on ClinicalTrials.gov