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Gene Expression Profiles in Chronic Periodontitis

NCT02467283 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 46

Last updated 2018-02-12

No results posted yet for this study

Summary

Current concepts of the causes of periodontitis implicate a bacterial infection as the primary cause of the disease. Several bacterial species residing in a biofilm on tooth surfaces are closely associated with periodontitis. Chronic periodontitis (CP) is initiated and sustained by bacterial plaque, but host defense mechanisms play an integral role in its pathogenesis.

Gene expression profiling is a powerful means of generating comprehensive genome-level data sets on diseases such as cancer, asthma, rheumatoid disorders and periodontitis, and provides significant insight information for these diseases. Gene expression profiling may provide an evidence for involving genes in the pathogenesis of CP and generate further information other than clinical signs and symptoms of CP.

The aim of this study was to identify gene-expression patterns of patients with chronic periodontitis by whole-transcriptome gene-expression analyses.

Conditions

  • Chronic Periodontitis

Interventions

GENETIC

Genom-based whole-genome transcriptomic

Gene expression profiling is a powerful means of generating comprehensive genome-level data sets.

Sponsors & Collaborators

  • Kocaeli University

    lead OTHER

Principal Investigators

  • Esra Guzeldemir-Akcakanat, DDS, PhD · Chair and Associate Professor of Dept. of Periodontology

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2013-02-28
Primary Completion
2015-08-31
Completion
2017-05-31

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT02467283 on ClinicalTrials.gov