Influence of Carbohydrate on Amino Acid Absorption From Dietary Protein (ICADP)

Summary

10 young males will be recruited to participate in a randomized double blinded crossover study to investigate the influence of concomitant intake of two different types of carbohydrate with protein hydrolysate on the absorption kinetics of protein-derived amino acids and the impact on myofibrillar protein synthesis. During the trial days the subjects will perform a bout of whole body resistance exercise and ingest a supplement of meat hydrolysate labeled with D5-phenylalanine together with randomized and double blinded type of carbohydrate consisting of either glucose or cluster dextrin.

The primary outcome is the time to obtain peak concentration of D5-phenylalanine after intake of meat hydrolysate with either glucose or cluster dextrin.

Hypotheses:

I) The cluster dextrin will increase the absorption of the amino acids from the meat hydrolysate, and thereby result in a faster rise and a higher peak in plasma amino acid concentration in the postprandial period.

II) The meat hydrolysate will increase the protein synthesis rate to a higher extent when combined with cluster dextrin than with glucose.

Conditions

• Muscle Protein Synthesis
• Amino Acid

Interventions

DIETARY_SUPPLEMENT

Meat Hydrolysate

25 grams of meat hydrolysate to maximally stimulate protein synthesis.

DIETARY_SUPPLEMENT

Cluster Dextrin

75 grams of Cluster Dextrin

DIETARY_SUPPLEMENT

Placebo

75 grams of Glucose

Sponsors & Collaborators

• University of Birmingham

  collaborator OTHER

• Bispebjerg Hospital

  lead OTHER

Principal Investigators

• Jacob L. Bülow, MD · Bispebjerg Hospital

• Lars Holm, Prof. · University of Birmingham

• Michael Kjaer, MD, prof. · Bispebjerg Hospital

• Sofus Sølyst, stud.med. · University of Copenhagen

• Mikkel Jensen, Stud.scient. · University of Copenhagen

Study Design

Allocation

RANDOMIZED

Purpose

BASIC_SCIENCE

Masking

DOUBLE

Model

CROSSOVER

Eligibility

Min Age

18 Years

Max Age

30 Years

Sex

MALE

Healthy Volunteers

Yes

Timeline & Regulatory

Start

2017-11-24

Primary Completion

2018-02-23

Completion

2018-02-23

Countries

• Denmark

Study Locations