MedTrace Logo

Bioavailability of Golden Rice Carotenoids in Humans

NCT00680355 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 14

Last updated 2013-07-01

No results posted yet for this study

Summary

This investigation protocol uses an isotope reference method to evaluate bioavailability of ß-C in rice and its bioconversion to vitamin A.

A well-nourished population will be fed hydroponically grown Golden Rice containing \~ 1 mg of β-carotene at day 8 after a reference dose of vitamin A at day 1. The blood samples will be collected up to 33 days after the doses. The absorption kinetics will be determined by tracking both vitamin A and β-carotene in human serum. Blood responses to Golden Rice β-carotene will be determined and evaluated. The vitamin A value of Golden Rice can thus be quantitatively determined.

Conditions

  • Healthy

Interventions

DIETARY_SUPPLEMENT

golden rice

An acute dose of cooked golden rice containing \~ 1 mg of ß-carotene

DIETARY_SUPPLEMENT

corn oil 0g

0 g of corn oil in the golden rice meal

DIETARY_SUPPLEMENT

corn oil 10g

10g corn oil in the golden rice meal

DIETARY_SUPPLEMENT

coren oil 5 g

golden rice meal with 5 g corn oil

Sponsors & Collaborators

  • Tufts University

    lead OTHER

Principal Investigators

  • Guangwen Tang, Ph. D · Tufts University

Study Design

Allocation
NON_RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
NONE
Model
SINGLE_GROUP

Eligibility

Min Age
40 Years
Max Age
70 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2004-08-31
Primary Completion
2012-08-31
Completion
2012-08-31

Countries

  • United States

Study Locations

More Related Trials

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT00680355 on ClinicalTrials.gov