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Effects of the Cornelian Cherry Supplementation on the Selected Physiological Parameters in Marathon Runners

NCT07194720 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 18

Last updated 2025-10-01

No results posted yet for this study

Summary

Growing body of evidence indicates favorable effects of Cornus mas (Cornelian cherry) supplements on cardiometabolic risk, including the improvement of HDL and glycemic indices, in line with vascular benefits. Experimental data feature bioactives from Cornelian cherry as potential modulators of vascular function and blood pressure, plausibly via endothelial nitric oxide-related pathways, with possible downstream effects on autonomic reflex control; nevertheless, such links in humans remain poorly explored to date, especially in terms of endurance training and hypoxia tolerance.

In this cross-over, placebo-controlled study, a group of healthy amateur long-distance runners underwent two stages of a four-week dietary intervention (separated by four weeks of washout period), receiving Cornelian cherry lyophilisate or placebo. Each supplementation stage was accompanied by the comprehensive evaluation of the cardio-respiratory parameters and endothelial function.

Conditions

  • Healthy

Interventions

DIETARY_SUPPLEMENT

Cornus mas lyophilisate

Participants receiving a Cornus mas (Cornelian cherry) lyophilisate for 4 weeks.

DIETARY_SUPPLEMENT

Placebo

Participants receiving a starch- and sugar-based placebo for 4 weeks.

Sponsors & Collaborators

  • Wrocław University of Environmental and Life Sciences

    collaborator UNKNOWN

  • Wroclaw Medical University

    lead OTHER

Study Design

Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
DOUBLE
Model
CROSSOVER

Eligibility

Min Age
45 Years
Max Age
75 Years
Sex
MALE
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2021-09-15
Primary Completion
2022-04-21
Completion
2022-04-21

Countries

  • Poland

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07194720 on ClinicalTrials.gov