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Inflammation-Related Endothelial Barrier Dysfunction in Patients With Apical Periodontitis

NCT07292363 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 45

Last updated 2025-12-31

No results posted yet for this study

Summary

Inflammation is a common factor in chronic periodontitis and systemic diseases. However, to date, there is no scientific evidence supporting a causal effect of inflammation caused by apical periodontitis on endothelial barrier dysfunction.

A case-control study was designed to evaluate serum levels of endothelial barrier dysfunction factors in a sample of healthy patients aged 25 to 55, with or without apical periodontitis, before endodontic treatment and 6 and 12 months after treatment.

The aim of this study is to investigate the potential relationship between the presence of chronic endodontic lesions and inflammation-related alterations of the endothelial barrier that may compromise its integrity, as well as to determine whether endodontic treatment can reduce these factors, thereby preventing changes in endothelial permeability.

Conditions

  • Apical Periodontitis
  • Healhty

Interventions

OTHER

Apical lesions cure

Treatment of apical lesions

Sponsors & Collaborators

  • University of Turin, Italy

    lead OTHER

Principal Investigators

  • Damiano Pasqualini, DDS Ass Prof · University of Turin, Department of Surgical Sciences - Dental School

Eligibility

Min Age
25 Years
Max Age
55 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2021-02-09
Primary Completion
2022-04-30
Completion
2025-10-16

Countries

  • Italy

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07292363 on ClinicalTrials.gov