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Evaluation of Matrix Metalloproteinase 8 Salivary Test for Diagnosis of Periodontitis

NCT03542630 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 100

Last updated 2021-09-29

No results posted yet for this study

Summary

Despite the great progress in understanding the causes of infertility, the reason for the failure of pregnancy has not been discovered among 25% of infertile couples. Some studies have shown the negative impact of periodontal disease on the reproductive potential of women. It is known that there is an elevated level of matrix metalloproteinase 8 (MMP8) in the gingival fluid of patients with periodontitis. It is possible to establish a fast diagnosis of periodontitis by using a non-invasive assay based on monoclonal antibodies to two epitopes of MMP-8. The goal of the research is to use the above described assay in order to compare the level of MMP8 in the gingival fluid of infertile patients with the control group of fertile women, depending on the existence of periodontal disease. It is expected to find significantly higher values of MMP8 in infertile patients in relation to the fertile patient with/without periodontitis. The prompt treatment of periodontitis in preconception care of this group of women could have a significant impact on the improvement of fertility and ability to achieve pregnancy.

Conditions

Interventions

DIAGNOSTIC_TEST

salivary MMP8 test

All female participants will make salivary MMP8 test and certain blood parameters to determine systemic inflammatory response

OTHER

periodontal examination

Periodontal examination by a specialist of periodontology will be made to all female participants, using periodontal probe and dental mirror.

OTHER

blood tests

All female participants who do not have recent blood tests will make new blood tests to determine certain blood parameters.

Sponsors & Collaborators

  • University of Zagreb

    lead OTHER

Principal Investigators

  • Božana Lončar Brzak, Assist.Prof. · University of Zagreb

Eligibility

Min Age
25 Years
Max Age
42 Years
Sex
FEMALE
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2018-01-01
Primary Completion
2021-05-01
Completion
2021-05-01

Countries

  • Croatia

Study Locations

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Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03542630 on ClinicalTrials.gov