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Dietary Intake of Tryptophan and Metformin Response

NCT02184832 · Status: COMPLETED · Phase: EARLY_PHASE1 · Type: INTERVENTIONAL · Enrollment: 20

Last updated 2016-03-16

No results posted yet for this study

Summary

This study will examine the influence of dietary intake of tryptophan on response to metformin. The investigators hypothesize that dietary tryptophan alteration will influence metformin response.

Conditions

  • Metformin Response
  • Fasting Glucose
  • Tryptophan Concentration
  • Metformin Concentration
  • Diet Tolerability

Interventions

DRUG

Metformin

2 doses of 500 mg metformin given approximately 12 hrs apart

OTHER

Low tryptophan diet

OTHER

High tryptophan diet

Sponsors & Collaborators

  • Massachusetts General Hospital

    lead OTHER

Principal Investigators

  • Geoffrey Walford, MD · Massachusetts General Hospital

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
QUADRUPLE
Model
CROSSOVER

Eligibility

Min Age
20 Years
Max Age
40 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2014-08-31
Primary Completion
2016-03-31
Completion
2016-03-31

Countries

  • United States

Study Locations

More Related Trials

Entities

Drugs

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT02184832 on ClinicalTrials.gov