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Mitochondrial Effects of C18:0 Supplementation in Humans

NCT02957838 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 23

Last updated 2017-11-27

No results posted yet for this study

Summary

The purpose of this crossover study is to determine whether nutritional supplementation of C18:0 in humans has mitochondrial effects as shown in Drosophila and human cell culture. We will compare a study cohort of patients with diagnosed type 2 diabetes with non-diabetics. Participants will undergo a 2-day low-fat vegan diet and will then be supplemented with a bolus of C18:0. Changes in the mitochondrial morphology and function of white blood cells will be scored by immunofluorescence and FACS analysis.

Conditions

  • Alteration of Mitochondrial Membrane
  • Type2 Diabetes
  • Fatty Acid Deficiency

Interventions

DIETARY_SUPPLEMENT

C18:0

Receives 24g of C18:0 in a low-fat banana milkshake.

DIETARY_SUPPLEMENT

mock

Low fat banana milkshake without C18:0 supplement.

Sponsors & Collaborators

  • German Cancer Research Center

    collaborator OTHER

  • University Hospital Heidelberg

    lead OTHER

Principal Investigators

  • Peter P Nawroth, MD · University Hospital Heidelberg

Study Design

Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
DOUBLE
Model
CROSSOVER

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2016-11-30
Primary Completion
2017-10-06
Completion
2017-11-18

Countries

  • Germany

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT02957838 on ClinicalTrials.gov