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Interaction Between St John's Wort and Metformin?

NCT01726764 · Status: COMPLETED · Phase: PHASE1 · Type: INTERVENTIONAL · Enrollment: 20

Last updated 2014-12-03

No results posted yet for this study

Summary

The goal of the study is to examine the difference of the pharmacokinetics of metformin with and without a 3 weeks pretreatment of St John's Wort. Furthermore secondary objectives include changes in GLP-1, C-peptide, serum-insulin and plasma-glucose during an oral glucose tolerance test, changes in OCT1 mRNA in plasma and changes in leptin and lipid-profile following this possible interaction.

Conditions

Interventions

OTHER

St John's Wort

DRUG

Metformin

Sponsors & Collaborators

  • University of Southern Denmark

    lead OTHER

Principal Investigators

  • Per Damkier, MD ph.d. · University of Southern Denmark

  • Tore B. Stage, M.Sc. Pharm · University of Southern Denmark

  • Kim Brøsen, Professor, MD · University of Southern Denmark

Study Design

Allocation
NA
Masking
NONE
Model
SINGLE_GROUP

Eligibility

Min Age
18 Years
Max Age
64 Years
Sex
MALE
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2013-01-31
Primary Completion
2013-06-30
Completion
2014-05-31

Countries

  • Denmark

Study Locations

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Entities

Drugs
Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT01726764 on ClinicalTrials.gov