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The Effects of Apple Derived Flavanols on Cardiovascular Disease Risk (FLAVASCULAR Study)

NCT02013856 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 42

Last updated 2016-12-02

No results posted yet for this study

Summary

Fruit and vegetable rich diets are associated with a reduced risk of cardiovascular disease (CVD). The protective effect may be ascribed to compounds contained within these foods, called flavonoids. Flavanols (epicatechin and procyanidins) are a particular group of flavonoids and are found mostly in apples, berry fruits, dark chocolate, tea and red wine. There is evidence to suggest that ingestion of flavanol rich foods and beverages beneficially alter 'markers' of CVD risk (e.g. blood pressure). The aim of this study is to determine the acute and chronic effects of apple derived flavanols on some risk markers for CVD.

Conditions

  • Blood Pressure

Interventions

DIETARY_SUPPLEMENT

Low Epicatechin and procyanidin

70 mg epicatechin and 65 mg procyanidins once daily for 28 days

DIETARY_SUPPLEMENT

High Epicatechin and procyanidin

140 mg epicatechin and 130 mg procyanidins once daily for 28 days

DIETARY_SUPPLEMENT

High procyanidin

No epicatechin and 130 mg procyanidins once daily for 28 days

DIETARY_SUPPLEMENT

Placebo

Placebo control once daily for 28 days

Sponsors & Collaborators

  • Quadram Institute Bioscience

    lead OTHER

Principal Investigators

  • Paul Dr Kroon, PhD · Quadram Institute Bioscience

Study Design

Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
DOUBLE
Model
CROSSOVER

Eligibility

Min Age
50 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2014-07-31
Primary Completion
2016-10-31
Completion
2016-10-31

Countries

  • United Kingdom

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT02013856 on ClinicalTrials.gov