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Bioavailability and Vascular Effects of Apple Polyphenols

NCT01097226 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 12

Last updated 2013-03-06

No results posted yet for this study

Summary

The main purpose of this study is to determine the oral bioavailability of flavanols (polyphenolic compounds) from apple granules and an apple extract delivered in a water based beverage at two different doses. We will also investigate the effects of apple flavanols on nitric oxide production.

Conditions

  • Healthy

Interventions

OTHER

Apple extract delivering 70 mg epicatechin

Delivered as a flavoured water based beverage

OTHER

Apple extract delivering 140 mg epicatechin

Delivered as a flavoured water based beverage

OTHER

Apple granules delivering 70 mg epicatechin

Delivered as a puree

OTHER

Water delivering no epicatechin

Delivered as flavoured water

Sponsors & Collaborators

  • Danisco

    collaborator INDUSTRY

  • Coressence LTD

    collaborator UNKNOWN

  • Quadram Institute Bioscience

    lead OTHER

Principal Investigators

  • Paul Kroon · Quadram Institute Bioscience

Study Design

Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
DOUBLE
Model
CROSSOVER

Eligibility

Min Age
45 Years
Max Age
70 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2010-04-30
Primary Completion
2010-12-31
Completion
2011-06-30

Countries

  • United Kingdom

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT01097226 on ClinicalTrials.gov