Effect of Cheese on Cardiovascular Risk

Summary

The main objective of the current study is to examine whether a high intake of regular-fat cheeses (Danbo and Cheddar) affect blood lipids differently than an isocaloric intake of either other fatty animal food products or of starchy carbohydrates. Furthermore, effects on fat digestibility, blood pressure, anthropometry, bile acid metabolism and insulin sensitivity is investigated.

To do this, a randomized crossover intervention study with 3x14 days full diet periods (cheese diet, meat diet or carb diet)will be conducted in 16 postmenopausal women. Between the diet periods there will be at least 14 days of wash-out where the subjects eat their habitual diets. Fasting blood samples will be drawn before and after the diet periods, and also a non-fasting blood sample will be drawn after the diet periods. Furthermore, total feces is collected the last 5 days of each diet period.

Conditions

• Hyperlipidemia

Interventions

OTHER

Dietary intervention: CHEESE (High cheese intake)

OTHER

Dietary intervention: MEAT (High Meat intake)

OTHER

Dietary intervention: CARB (High Carbohydrate intake)

Sponsors & Collaborators

• The Danish Dairy Research Foundation, Denmark

  collaborator OTHER

• Dairy Research Institute

  collaborator OTHER

• Dairy Farmers of Canada

  collaborator OTHER

• Centre National Interprofessionel de l'Economie Laitière

  collaborator OTHER

• Dairy Australia

  collaborator INDUSTRY

• Nederlandse Zuivel Organisatie

  collaborator OTHER

• University of Copenhagen

  lead OTHER

Principal Investigators

• Arne Astrup, Prof, MD · Head of Department of Nutrition, Exercise and Sports

Study Design

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

NONE

Model

CROSSOVER

Eligibility

Min Age

45 Years

Max Age

68 Years

Sex

FEMALE

Healthy Volunteers

Yes

Timeline & Regulatory

Start

2013-01-31

Primary Completion

2013-08-31

Completion

2014-11-30

Countries

• Denmark

Study Locations