The Effect of Alcohol on Food Reward

Summary

Rationale

It has been shown in several studies that alcohol increases subsequent food intake. However, moderate alcohol consumption has no clear effects on hunger and satiety hormones. In the Western world, where palatable food is highly available, food reward may play an important role in food intake. Alcohol consumption is known to stimulate neurotransmitters important for food reward and may therefore stimulate the reward response on a subsequent meal. This may lead to higher food consumption than when no alcohol is consumed. It is hypothesized that the reward response of food or beverages can already be generated when food or beverages are sensed in the mouth, because oral nutrient sensing is known to induce a satiety response (i.e. the cephalic phase response). Moreover, taste buds directly signal brain areas closely connected to the reward areas in the brain.

Primary objective

* To determine whether moderate alcohol consumption influences subsequent food reward, as measured by questionnaires on food 'wanting' and food 'liking', and salivary and blood parameters related to reward.

Secondary objectives

* To determine whether food reward is different when food is consumed than when food is sensed in the mouth, as measured by questionnaires on food 'wanting' and food 'liking', and salivary and blood parameters related to food reward.
* To determine whether moderate alcohol consumption influences subsequent food reward differently when food is consumed than when food is sensed in the mouth, as measured by questionnaires on food 'wanting' and food 'liking', and salivary and blood parameters related to food reward.

Conditions

• Obesity
• Body Weight

Interventions

OTHER

Orange juice

OTHER

maltodextrin

OTHER

Vodka

OTHER

butter cake MSF

chewing on 40 gram cake for 6 minutes and before swallowing expectorating the bolus in cup.

OTHER

butter cake consumption

chewing for 6 min on 40 gram cake and then swallow it.

Sponsors & Collaborators

• Foundation for Alcohol Research (SAR), The Netherlands

  collaborator UNKNOWN

• Ministry of Economic Affairs, The Netherlands

  collaborator UNKNOWN

• Henk FJ Hendriks

  lead OTHER

Principal Investigators

• Henk Hendriks, PhD · TNO Zeist, The Netherlands

Study Design

Allocation

RANDOMIZED

Purpose

BASIC_SCIENCE

Masking

SINGLE

Model

CROSSOVER

Eligibility

Min Age

25 Years

Max Age

50 Years

Sex

MALE

Healthy Volunteers

Yes

Timeline & Regulatory

Start

2012-10-31

Primary Completion

2012-12-31

Completion

2012-12-31

Countries

• Netherlands

Study Locations