MedTrace Logo

Skeletal Muscle Response to Amino Acids and Load Carriage Exercise

NCT01714479 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 40

Last updated 2017-07-21

No results posted yet for this study

Summary

Warfighters often experience physical overload, as the uniform and associated gear that they carry burdens them with substantial loads. The loads increase energy expenditure to levels that exceed a Warfighter's typical energy intake. The typical assault load is approximately 25 kg, although loads as high as 55 kg are often carried, which when combined with extreme energy expenditures can degrade health and performance, and increase the risk of injury. Branched-chain amino acid (leucine) supplementation may confer protection against the negative effects of operational stress by stimulating muscle protein synthesis and reducing degradation. This study will determine if leucine-enriched nutrition supplementation confers protection against the negative consequences of sustained load carriage exercise, and explore the mechanisms by which leucine might impart protection.

Conditions

  • Muscle Loss
  • Muscle Anabolism
  • Muscle Performance

Interventions

OTHER

Leucine-enriched nutritional supplement

A protein and carbohydrate supplement with high levels of leucine

OTHER

Placebo

Sponsors & Collaborators

  • US Army Natick Soldier Research, Development & Engineering Center

    collaborator UNKNOWN

  • United States Army Research Institute of Environmental Medicine

    lead FED

Principal Investigators

  • Stefan M Pasiakos, Ph.D. · United States Army Research Institute of Environmental Medicine

Study Design

Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
TRIPLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
39 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2012-10-31
Primary Completion
2013-11-30
Completion
2013-11-30

Countries

  • United States

Study Locations

More Related Trials

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT01714479 on ClinicalTrials.gov