Vegetable Consumption in Relation to Health

Summary

Rationale: Consumption of vegetables is generally considered to be associated with several positive effects on health. Vegetables are a heterogeneous group of our diet which is rich in bio-actives. The vegetables contain a range of vitamins, minerals, dietary fibres and phytochemicals like potassium, flavonoids, carotenoids, and vitamin C. The recommended intake of vegetables by the Dutch Health Council is 200 grams daily (Health Council, 2006).

Health in this project is defined as the possibility of a subject to change and adapt easily in response to a certain challenge. Healthy subjects show resilience in different physiological processes related to oxidative stress, metabolic stress, neurological stress and inflammatory stress. The reaction/response to a challenge might be changed when subjects have consumed more or less vegetables and have an improved health status. The response might also differentiate between subjects differing in BMI (healthy weight versus overweight/obese). Supplementation of vegetables will be provided in two conditions: a low and a high daily intake (50 versus 200 grams daily). An intervention known to have positive effects on health is weight loss. This will be studied in relation to health (the reaction to the challenge test) as well.

A beneficial effect is present when 5% improvement of health markers is shown with vegetable supplementation, similar as is known from weight loss studies.

Objective: The primary objective of the present study is to set-up a methodology to investigate health based on the resilience to challenge. A secondary objective is the effectiveness of the challenge concept with a food intervention. The vegetable supplementation study is a first example to test the challenge concept. Therefore, vegetable consumption according to the recommendations of the Dutch Health Council of 200 grams of vegetables daily will be studied with an exercise challenge test, to investigate the beneficial 'health' effects.

Conditions

• Health
• Obesity
• Oxidative Stress

Interventions

DIETARY_SUPPLEMENT

Vegetables

200 or 50 grams of vegetables daily for four weeks

DIETARY_SUPPLEMENT

energy restriction

Consume about 1000 kcal less daily, for four weeks, as a positive control to the vegetables interventions.

Sponsors & Collaborators

• Netherlands: Ministry of Health, Welfare and Sports

  collaborator OTHER_GOV

• TNO

  lead OTHER

Principal Investigators

• Wilrike Pasman, PhD · TNO

• Ineke Klöpping-Ketelaars, PhD, MD · TNO

Study Design

Allocation

RANDOMIZED

Purpose

BASIC_SCIENCE

Masking

NONE

Model

PARALLEL

Eligibility

Min Age

18 Years

Max Age

45 Years

Sex

MALE

Healthy Volunteers

Yes

Timeline & Regulatory

Start

2009-01-31

Primary Completion

2009-12-31

Completion

2010-12-31

Countries

• Netherlands

Study Locations