Intensive Chemo-Radiotherapy With Peripheral Blood Progenitor Cell Rescue for Children With Advanced Neuroblastoma and Sarcomas
NCT00165139 · Status: COMPLETED · Phase: PHASE2 · Type: INTERVENTIONAL · Enrollment: 20
Last updated 2009-11-02
Summary
The main purpose of this study is to determine the short and long term side effects of a very intensive treatment, which includes combinations of chemotherapy drugs followed by radiation therapy and two transplants supported by peripheral blood progenitor cells (stem cells), for children with advanced stage neuroblastoma and sarcomas.
Conditions
- Neuroblastoma
- Ewings Sarcoma
- Non-rhabdomyosarcoma Soft Tissue Sarcoma
Interventions
- DRUG
-
Vincristine
Described under detailed description
- DRUG
-
Described under detailed description
- DRUG
-
Adriamycin
Described under detailed description
- DRUG
-
Etoposide (VP-16)
Described under detailed description
- DRUG
-
Described under detailed description
- DRUG
-
Described under detailed description
- DRUG
-
Melphalan
Described under detailed description
- DRUG
-
Ifosfamide
Described under detailed description
- DRUG
-
G-CSF (granulocyte-colony stimulating factor)
Described under detailed description
- DRUG
-
Mesna
Described under detailed description
Sponsors & Collaborators
- collaborator OTHER
-
Children's Hospital of Philadelphia
collaborator OTHER - lead OTHER
Principal Investigators
-
Lisa Diller, MD · Dana-Farber Cancer Institute
Study Design
- Allocation
- NON_RANDOMIZED
- Purpose
- TREATMENT
- Masking
- NONE
- Model
- SINGLE_GROUP
Eligibility
- Max Age
- 19 Years
- Sex
- ALL
- Healthy Volunteers
- No
Timeline & Regulatory
- Start
- 1996-01-31
- Primary Completion
- 2000-11-30
- Completion
- 2009-02-28
Countries
- United States
Study Locations
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