Combination Chemotherapy With or Without Etoposide Followed By an Autologous Stem Cell Transplant in Treating Young Patients With Previously Untreated Malignant Brain Tumors

Summary

RATIONALE: Drugs used in chemotherapy work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. A bone marrow or peripheral stem cell transplant using stem cells from the patient may be able to replace blood-forming cells that were destroyed by chemotherapy. This may allow more chemotherapy to be given so that more tumor cells are killed.

PURPOSE: This phase III trial is studying how well giving combination chemotherapy with or without etoposide followed by an autologous stem cell transplant works in treating young patients with previously untreated malignant brain tumors.

Conditions

• Brain and Central Nervous System Tumors

Interventions

DRUG

carboplatin

Given IV

DRUG

cisplatin

Given IV

DRUG

cyclophosphamide

Given IV

DRUG

etoposide

Given IV and orally

DRUG

methotrexate

Given IV

DRUG

temozolomide

Given orally

DRUG

thiotepa

Given IV

DRUG

vincristine sulfate

Given IV

PROCEDURE

autologous bone marrow transplantation

Given on day 0

PROCEDURE

autologous hematopoietic stem cell transplantation

Given on day 0

PROCEDURE

peripheral blood stem cell transplantation

Given on day 0

RADIATION

radiation therapy

Some patients undergo radiation therapy once daily, 5 days a week for 4-6 weeks.

Sponsors & Collaborators

• Children's Hospital Los Angeles

  lead OTHER

Principal Investigators

• Jonathan L. Finlay, MB, ChB · Children's Hospital Los Angeles

• Girish Dhall, MD · Children's Hospital Los Angeles

• Kelley Haley, RN, BSN · Children's Hospital Los Angeles

Study Design

Purpose

TREATMENT

Eligibility

Max Age

10 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2004-03-31

Primary Completion

2010-12-31

Countries

• United States
• Australia
• Canada
• New Zealand
• Switzerland

Study Locations