Combination Chemotherapy and Radiation Therapy in Treating Young Patients With Newly Diagnosed Hodgkin Lymphoma

Summary

This phase III trial is studying how well giving combination chemotherapy together with radiation therapy works in treating young patients with newly diagnosed Hodgkin lymphoma. Drugs used in chemotherapy work in different ways to stop the growth of cancer cells, either by killing the cells or by stopping them from dividing. Radiation therapy uses high energy x-rays to kill cancer cells. Giving combination chemotherapy together with radiation therapy may kill more cancer cells.

Conditions

• Childhood Nodular Lymphocyte Predominant Hodgkin Lymphoma
• Stage III Childhood Hodgkin Lymphoma
• Stage IV Childhood Hodgkin Lymphoma

Interventions

BIOLOGICAL

bleomycin sulfate

Given IV or SC

DRUG

doxorubicin hydrochloride

Given IV

DRUG

liposomal vincristine sulfate

Given IV

DRUG

vinorelbine tartrate

Given IV

DRUG

cyclophosphamide

Given IV

DRUG

etoposide phosphate

Given IV

DRUG

prednisone

Given IV

BIOLOGICAL

filgrastim

Given IV or SC

DRUG

ifosfamide

Given IV

Sponsors & Collaborators

• National Cancer Institute (NCI)

  collaborator NIH

• Children's Oncology Group

  lead NETWORK

Principal Investigators

• Kara Kelly, MD · Children's Oncology Group

Study Design

Allocation

NON_RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Model

PARALLEL

Eligibility

Max Age

21 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2009-12-07

Primary Completion

2012-03-01

Completion

2022-03-31

Countries

• United States
• Australia
• Canada
• Israel
• Puerto Rico

Study Locations