Neuroblastoma is a malignant embryonal tumor of the sympathetic nervous system that usually arises in the adrenal medulla or paraspinal ganglia and occurs predominantly in young children.
Johnson & Johnson invests over $1 billion in a new Pennsylvania cell therapy manufacturing facility for cancer and neurological diseases. The expansion addresses growing demand for advanced therapies while highlighting workforce training challenges in GMP environments. Other developments include new cell line technology for viral vector production and CRISPR-edited CAR-T manufacturing partnerships.
Researchers are developing personalized treatment approaches for rare and pediatric cancers using genetic profiling, AI-driven dosing, and 3D-printed medications to improve outcomes while reducing long-term toxicity.
| NCT ID | Title | Status | Phase |
|---|---|---|---|
| NCT07595666 |
Comparison of NeuroEXPLORER PET/CT Versus Standard-of-care PET/CT of the Head and Neck Region. |
ENROLLING_BY_INVITATION | NA |
| NCT07584499 |
Phase I Study of Becotatug Vedotin for Safety and Efficacy in EGFR-Positive Pediatric Relapsed/Refractory or Metastatic Solid Tumors |
RECRUITING | PHASE1 |
| NCT07518654 |
Phase I Clinical Trial of ThINKK Adoptive Immunotherapy After Allogeneic Hematopoietic Transplantation in Children With Leukemia or Neuroblastoma |
NOT_YET_RECRUITING | PHASE1 |
| NCT07516678 |
Serial ctDNA and Molecular Residual Disease Monitoring in Neuroblastoma |
RECRUITING | |
| NCT07399821 |
An Imaging Study of Anti-GD2-800CW in Patients With Neuroblastoma |
RECRUITING | PHASE1/PHASE2 |
| NCT07358260 |
B7-H3.CD28Z.CART in Solid Tumors |
NOT_YET_RECRUITING | PHASE1 |
| NCT07261241 |
NANT 2021-02: Randomized MIBG With Vorinostat/Dinutuximab/Vorinostat + Dinutuximab |
NOT_YET_RECRUITING | PHASE2 |
| NCT07223606 |
Fecal Microbiota Transplant for Neuroblastoma in a Single Patient |
NO_LONGER_AVAILABLE | |
| NCT07195500 |
Clinical Application of Somatostatin Receptor and Norepinephrine Transporter Targeted Imaging for Diagnosis and Staging of Neuroblastoma and Pheochromocytoma/Paraganglioma |
RECRUITING | |
| NCT07172958 |
Selective Antigen Specific T Cells and CAR T Cells in Subjects With Relapsed/Refractory Embryonal Tumors (SABRE) |
RECRUITING | PHASE1 |
