Combination Chemotherapy Followed by Radiation Therapy in Treating Young Patients With Newly Diagnosed Hodgkin's Lymphoma

Summary

This phase III trial is studying how well combination chemotherapy works when given before radiation therapy and/or additional chemotherapy in treating young patients with newly diagnosed Hodgkin's lymphoma. Drugs used in chemotherapy work in different ways to stop the growth of cancer cells, either by killing the cells or by stopping them from dividing. Radiation therapy uses high-energy x-rays to kill cancer cells. Giving more than one drug (combination chemotherapy) and giving them together with radiation therapy may kill more cancer cells.

Conditions

• Childhood Favorable Prognosis Hodgkin Lymphoma
• Childhood Lymphocyte Depletion Hodgkin Lymphoma
• Childhood Mixed Cellularity Hodgkin Lymphoma
• Childhood Nodular Sclerosis Hodgkin Lymphoma
• Stage I Childhood Hodgkin Lymphoma
• Stage II Childhood Hodgkin Lymphoma

Interventions

RADIATION

radiation therapy

Undergo radiation therapy

DRUG

doxorubicin hydrochloride

Given IV

DRUG

vincristine sulfate

Given IV

DRUG

prednisone

Given orally

DRUG

cyclophosphamide

Given IV

DRUG

ifosfamide

Given IV

DRUG

vinorelbine tartrate

Given IV

DRUG

dexamethasone

Given IV

DRUG

etoposide phosphate

Given IV

DRUG

cisplatin

Given IV

DRUG

cytarabine

Given IV

BIOLOGICAL

filgrastim

Given IV or subcutaneously

Sponsors & Collaborators

• National Cancer Institute (NCI)

  collaborator NIH

• Children's Oncology Group

  lead NETWORK

Principal Investigators

• Frank Keller, MD · Children's Oncology Group

Study Design

Allocation

NA

Purpose

TREATMENT

Masking

NONE

Model

SINGLE_GROUP

Eligibility

Max Age

21 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2006-02-28

Primary Completion

2012-03-31

Completion

2019-06-30

Countries

• United States

Study Locations