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Effects of Plant Foods on Gastrointestinal and Cardiometabolic Health

NCT07586111 · Status: RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 248

Last updated 2026-05-14

No results posted yet for this study

Summary

The aim of this randomised controlled trial is to investigate the effects of plant foods on gastrointestinal and cardiometabolic health in healthy adults aged 30-70 years old. The main question it will answer is "what is the effect of plant foods on alpha-diversity of the gut microbiota?".

Researchers will compare two diets containing plant foods to see if they have different effects on gastrointestinal and cardiometabolic health.

Participants will be asked to replace all their meals, snacks and drinks with those provided by the study team for four weeks (6 days/week). Participants will also be asked to attend the research facility on three occasions to:

* Provide a blood sample
* Provide a urine sample
* Provide a stool sample
* Have their body composition assessed
* Have an ultrasound of their artery (arm)
* Have their blood pressure measured
* Answer questionnaires related to dietary intake, mental health, physical activity, quality of life, diet acceptability and adherence

Conditions

  • Nutrition
  • Healthy Adult Volunteers

Interventions

OTHER

A diet containing different plant foods

Study meals, snacks and drinks will be provided that contain plant foods for four weeks (6 days a week). Participants will follow guidance in self-selecting foods on one day per week.

OTHER

A diet containing plant foods

Study meals, snacks and drinks will be provided that contain plant foods for four weeks (6 days a week). Participants will follow guidance in self-selecting foods on one day per week.

Sponsors & Collaborators

  • Biotechnology and Biological Sciences Research Council

    collaborator OTHER

  • University of Southampton

    collaborator OTHER

  • University of Leeds

    collaborator OTHER

  • King's College London

    lead OTHER

Study Design

Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
TRIPLE
Model
PARALLEL

Eligibility

Min Age
30 Years
Max Age
70 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2026-04-30
Primary Completion
2028-10-31
Completion
2028-11-30

Countries

  • United Kingdom

Study Locations

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Entities

Companies

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07586111 on ClinicalTrials.gov