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Effects on the Olfactory Epithelium and the Olfactory Nerve From Exposure to Diesel Exhaust

NCT07237958 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 40

Last updated 2025-11-20

No results posted yet for this study

Summary

The goal of this study is to study the effect exposure to air pollution and its effect on development of dementia.

Does the diesel exhaust change the function of the olfactory system?

Have the exposures measurable effects on the sense of smell and cognitive ability?

Forty people are exposed to diesel exhaust exhaust and filtered air. The exposures are blinded and in a randomized order. Both groups undergo biopsies of the olfactory epithelium in the nose under local anesthesia after the exposures and after performing cognitive test.

Conditions

  • Alzheimer Disease (AD)
  • Dementia Alzheimer Type
  • Air Pollution Exposure

Interventions

OTHER

Diesel Exhaust Particles

During exposure to diesel exhaust, participants alternate between 15-minute periods of rest and exercise on an ergometer cycle with a workload that results in a minute ventilation of 20L/min/m² body surface area. Symptom recording is done every 30 minutes, following a routine based on a modified Borg scale.

OTHER

Filtered air

During exposure to filtered air, participants alternate between 15-minute periods of rest and exercise on an ergometer cycle with a workload that results in a minute ventilation of 20L/min/m² body surface area. Symptom recording is done every 30 minutes, following a routine based on a modified Borg scale

Sponsors & Collaborators

  • University Hospital, Umeå

    collaborator OTHER

  • University of Eastern Finland

    collaborator OTHER

  • Czech Academy of Sciences

    collaborator OTHER

  • Umeå University

    lead OTHER

Study Design

Allocation
RANDOMIZED
Purpose
DIAGNOSTIC
Masking
QUADRUPLE
Model
CROSSOVER

Eligibility

Min Age
20 Years
Max Age
70 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2019-02-01
Primary Completion
2023-05-12
Completion
2023-05-19

Countries

  • Sweden

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07237958 on ClinicalTrials.gov