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Health Effects of Diesel Exhaust in Asthmatic Patients: A Real-world Study in a London Street

NCT00127062 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 60

Last updated 2019-11-05

Study results available
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Summary

Acute exposure to diesel exhaust under normal city conditions leads to a worsening of symptoms of asthma, with reduction in lung function in asthmatic nonsmoking adults, dependent on the exposure dose and on the background severity of asthma.

The worsening asthma is accompanied by increased oxidative stress and inflammation in the lungs.

Conditions

Interventions

OTHER

Oxford street

2 h walk around Oxford street

OTHER

Hyde park

2 h walk around Hyde park

Sponsors & Collaborators

  • Health Effects Institute

    collaborator OTHER

  • Imperial College London

    lead OTHER

Principal Investigators

  • Paul Cullinan, MD · Imperial College London

  • Fan Chung, MD · Imperial College London

  • Mark Nieuwenhuijsen, PhD · Imperial College London

  • Jim Zhang, PhD · Rutgers U & UMDNJ

Study Design

Allocation
NON_RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
NONE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
55 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2003-05-31
Primary Completion
2006-08-31
Completion
2006-08-31

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Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT00127062 on ClinicalTrials.gov