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Health Effects of Wood Smoke and Traffic-Related Air Pollution Exposures: a Necessary Comparison

NCT06749093 · Status: NOT_YET_RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 48

Last updated 2024-12-27

No results posted yet for this study

Summary

Accumulating evidence demonstrates that breathing air pollutants leads to devastating increases in sickness and death worldwide over time. However, there is little data comparing the effects of different types of air pollution on health. In Canada, traffic-related air pollution and wood smoke (wildfires and wood burning for heating) are very common air pollutants. This study aims to safely complete a controlled human exposure study to test how these air pollution types acutely affect health.

Conditions

  • Healthy Individuals
  • Allergic Rhinitis

Interventions

OTHER

Filtered Air (FA)

Exposure to HEPA filtered air, as a control

OTHER

Wood Smoke (WS)

Wood smoke (WS) standardized to 300µg/m³ of particulate matter with a diameter of 2.5 micrometers or less (PM2.5).

OTHER

Diesel Exhaust (DE)

Diesel exhaust (DE) standardized to 300µg/m³ of particulate matter with a diameter of 2.5 micrometers or less (PM2.5).

OTHER

Diesel Exhaust and Wood Smoke (DEWS)

Combined diesel exhaust and wood smoke standardized to 300µg/m³ of particulate matter with a diameter of 2.5 micrometers or less (PM2.5).

Sponsors & Collaborators

  • University of British Columbia

    lead OTHER

Principal Investigators

  • Chris Carlsten, MD · University of British Columbia

Study Design

Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
TRIPLE
Model
CROSSOVER

Eligibility

Min Age
19 Years
Max Age
40 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2025-07-01
Primary Completion
2026-12-31
Completion
2029-12-31

Countries

  • Canada

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06749093 on ClinicalTrials.gov