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Health Effects of Occupational Exposure to Combustion Particles - a Study on Volunteers Performing as Train Conductors

NCT03104387 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 29

Last updated 2020-08-10

No results posted yet for this study

Summary

Ambient air pollution is a complex mixture of gaseous pollutants and particulate matter (PM). PM has a recognized important role in human health. There is a strong scientific consensus on the independent association of PM and adverse cardiovascular and respiratory effects, as well as cancer. It is reasonable to expect that the smaller particles (ultrafine particles, UFP) may have an enhanced toxicity relative to other PM size fractions, due to physical properties and potential to translocation beyond the lung.

A recent Danish report concluded that train conductors on a working day, and in two specific diesel engine trains, are exposed to higher concentrations of diesel exhaust than by constant stay in a busy street. Indeed, the average exposure for train conductors on such engines was around 100,000-150,000 UFP per cm3 as compared with around 40,000 per cm3 on a busy street in Copenhagen \[1\]. The aim of this study is to investigate if this occupational exposure is associated with vascular and respiratory impairment and DNA damage.

Conditions

  • Cardiovascular Function
  • Genotoxicity

Interventions

OTHER

Electric train

Exposure to air with low level of ultrafine particles (Electric train)

OTHER

Diesel train

Exposure to air with high level of ultrafine particles (Diesel train)

Sponsors & Collaborators

  • National Research Centre for the Working Environment, Denmark

    collaborator OTHER_GOV

  • University of Copenhagen

    lead OTHER

Principal Investigators

  • Peter Moller, PhD · University of Copenhagen

Study Design

Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
NONE
Model
CROSSOVER

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2017-05-16
Primary Completion
2018-09-30
Completion
2020-05-01

Countries

  • Denmark

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03104387 on ClinicalTrials.gov