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The Effects of Diesel Exhaust Inhalation on Vascular Function - the Role of Endothelin

NCT00745693 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 15

Last updated 2024-05-17

No results posted yet for this study

Summary

The purpose of this study is to identify the role of endothelin 1 (a natural vasoconstrictor) in the adverse vascular effects demonstrated after exposure to air pollution

Conditions

  • Coronary Disease

Interventions

DRUG

Endothelin-1

Intra-arterial infusion of Endothelin-1 at 5pmol/min for 1 hour during venous occlusion plethysmography

DRUG

BQ-123 and BQ-788

1 hour intra-arterial infusion of BQ-123 at 10nmol/min followed by co-infusion of BQ-788 at 1nmol/min for a further hour during forearm venous occlusion plethysmography

Sponsors & Collaborators

  • Umeå University

    collaborator OTHER

  • University of Edinburgh

    lead OTHER

Principal Investigators

  • Jeremy P Langrish, MB BCh MRCP · University of Edinburgh

  • Anders Blomberg, MD · Umeå University

  • Thomas Sandström, MD · Umeå University

  • David E Newby, MD FRCP · University of Edinburgh

Study Design

Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
TRIPLE
Model
CROSSOVER

Eligibility

Min Age
18 Years
Max Age
35 Years
Sex
MALE
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2008-03-31
Primary Completion
2008-05-31
Completion
2008-05-31

Countries

  • Sweden

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT00745693 on ClinicalTrials.gov