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Iron Absorption and Losses in Young South African Women Living Without and With Overweight and Obesity

NCT07081152 · Status: RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 70

Last updated 2026-03-23

No results posted yet for this study

Summary

Young women living with obesity (OB) have a greater risk of developing iron deficiency. Plus, the risk of anemia and/or ID in young women living with overweight (OW) and obesity (OB) is further increased by inadequate dietary intake and/or poor bioavailability of iron, as well as gastrointestinal and menstrual iron losses. It is not certain whether women living with OW/OB can meet their iron requirements from their day-to-day diet.

The aim of this study is to compare iron absorption and losses over a long period between women living with and without OW and OB. Secondary outcomes include iron and inflammation status, as well as dietary iron intake.

Conditions

Interventions

OTHER

Ferrous sulfate

All participants will receive a single dose of 15 mg of iron as isotopically prepared ferrous sulfate labelled with 57Fe. The iron dose will be given with ascorbic acid to attain a molar ratio of ascorbic acid:iron of 2:1

Sponsors & Collaborators

  • King's College London

    collaborator OTHER

  • ETH Zurich (Switzerland)

    collaborator OTHER

  • Linda Malan

    lead OTHER

Principal Investigators

  • Linda Malan, PhD · Centre of Excellence for Nutrition, North-West University

  • Mary Uyoga, PhD · Centre of Excellence for Nutrition, North-West University

Study Design

Allocation
NON_RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
NONE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
35 Years
Sex
FEMALE
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2025-07-24
Primary Completion
2027-06-30
Completion
2027-06-30

Countries

  • South Africa

Study Locations

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Entities

Diseases
Companies

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07081152 on ClinicalTrials.gov