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Systemic and White Adipose Tissue Inflammatory Profile in Lean Versus Obese Individuals

NCT04078776 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 12

Last updated 2022-05-17

No results posted yet for this study

Summary

This study will compare the systemic and white adipose tissue inflammatory profile of individuals who are classified as lean and obese. Blood and white adipose tissue samples will be collected in the fasted state to assess inflammatory status.

There is evidence to suggest that markers of inflammation in the blood and white adipose tissue increase with increasing levels of obesity. However, the white adipose tissue total protein content and phosphorylation of proteins involved in inflammatory pathways has not previously been compared between lean and obese individuals.

The investigators hypothesise that obese individuals will have increased levels of inflammation in the blood and white adipose tissue, compared to their lean counterparts.

Conditions

Interventions

OTHER

No intervention

There is no intervention in this study

Sponsors & Collaborators

  • Loughborough University

    lead OTHER

Principal Investigators

  • Oonagh Markey, BSc, PhD · Vice-Chancellor's Research Fellow, Loughborough University

Eligibility

Min Age
18 Years
Max Age
40 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2019-10-25
Primary Completion
2020-08-01
Completion
2020-08-01

Countries

  • United Kingdom

Study Locations

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Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04078776 on ClinicalTrials.gov