MedTrace Logo

Changes in Iron Absorption and Availability Before and After Weight Loss in Obese Pre-menopausal Women and Men.

NCT01347905 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 43

Last updated 2015-06-09

No results posted yet for this study

Summary

The objective of this study is to investigate if weight loss, in particular due to adipose tissue loss, in obese patients will reverse the obesity-related reduction of iron absorption, and if this is due to a decrease in hepcidin concentrations. Additionally, the investigators will investigate changes in iron incorporation into erythrocytes due to a reduction of iron sequestration by the adipose tissue and reticuloendothelial system. The investigators expect that by decreasing adiposity, circulating hepcidin levels will decrease, iron absorption and incorporation into erythrocytes will increase and as a result iron status will be improved.

Conditions

Interventions

OTHER

Stable-isotope techniques

Iron absorption will be estimated using stable-isotope techniques where incorporation of 57Fe and 58Fe into erythrocytes is measured 14 days after administration. The subjects will provide an initial blood sample (20ml) and then receive a test drink, containing 6 mg of 57Fe labeled ferrous sulphate. One hour later, 2 ml of an aqueous solution containing 100 μg 58Fe, as iron citrate in 250cc of normal saline will be infused over 50 min. Post infusion a 4ml blood sample will be taken. This procedure will be performed at baseline (6 weeks post-surgery) and at the end of the study (6-7 months post baseline).

Sponsors & Collaborators

  • Universidad de Monterrey

    collaborator OTHER

  • Mexican National Institute of Public Health

    collaborator OTHER_GOV

  • Swiss Federal Institute of Technology

    collaborator OTHER

  • Unilever R&D

    collaborator INDUSTRY

  • Wageningen University

    lead OTHER

Principal Investigators

  • Michael B Zimmermann, MD PHD · Wageningen University

Eligibility

Min Age
18 Years
Max Age
50 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2011-02-28
Primary Completion
2013-09-30
Completion
2013-12-31

Countries

  • Mexico

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT01347905 on ClinicalTrials.gov