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Evaluation of the Effect of Body Weight and Composition on Iron Absorption and Blood Volume

NCT01884506 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 64

Last updated 2013-10-14

No results posted yet for this study

Summary

A total of 75 subjects will be recruited for this study (25 normal weight, 25 overweight, 25 obese). In each subject blood volume will be determined using the minimally invasive carbon monoxide-rebreathing method (substudy 1) and iron absorption will be measured from a test meal labeled with stable iron isotopes. The effect of ascorbic acid on iron absorption will further be determined using a second labeled test meal (substudy 2). In addition, inflammation, hepcidin and iron status will be determined. In order to study the effect of body fat content on blood volume and iron absorption weight and height will be measured, and body fat will de determined by dual energy X-ray absorptiometry.

Conditions

Interventions

DIETARY_SUPPLEMENT

labeled iron solution

labeled iron as ferrous sulfate (6mg/test meal)

DIETARY_SUPPLEMENT

labeled iron solution and ascorbic acid

labeled iron as ferrous sulfate plus ascorbic acid (6mg:30mg /test meal)

Sponsors & Collaborators

  • Wageningen University

    collaborator OTHER

  • Universidad de Monterrey

    collaborator OTHER

  • Swiss Federal Institute of Technology

    lead OTHER

Principal Investigators

  • Isabelle Aeberli, PhD · ETH Zurich

Study Design

Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
DOUBLE
Model
CROSSOVER

Eligibility

Min Age
18 Years
Max Age
45 Years
Sex
FEMALE
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2013-06-30
Primary Completion
2013-08-31
Completion
2013-10-31

Countries

  • Switzerland

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT01884506 on ClinicalTrials.gov