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Short-term Fat Overfeeding on the Effects of Liver Metabolism

NCT05962190 · Status: RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 26

Last updated 2023-07-27

No results posted yet for this study

Summary

Despite work showing the overconsumption of saturated fatty acids (SFA) to be metabolically deleterious, debate continues about whether there is a link between SFA and cardiovascular disease risk. To explore this, we are undertaking a human in vivo parallel-design study, comparing two isocaloric high-fat diets; one enriched with SFA and the other enriched with unsaturated fatty acids (UFAs), to determine the impact of dietary fat composition on postprandial metabolism, liver fat, cardiac fat and cardiac function.

Conditions

  • Liver Fat
  • Cardiac Function
  • Lipid Disorder
  • Adiposity

Interventions

BEHAVIORAL

Diet

High fat (\~60% of total energy intake) diet enriched with either SFA or UFA

Sponsors & Collaborators

  • University of Oxford

    lead OTHER

Principal Investigators

  • Leanne Hodson, PhD · University of Oxford

Study Design

Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
NONE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
65 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2023-02-15
Primary Completion
2028-02-29
Completion
2028-02-29

Countries

  • United Kingdom

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05962190 on ClinicalTrials.gov