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High Intensity Resistance Training + Creatine in Perimenopause

NCT07027800 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 55

Last updated 2026-03-11

No results posted yet for this study

Summary

Purpose: The aims of the study are to investigate the effects of high-intensity resistance training (HIRT) with or without creatine monohydrate (CM) supplementation on three key areas: muscle characteristics, brain health, and metabolism/protein dynamics.

Participants: 51 healthy, perimenopausal women between 38-60 years old. Procedures: In a randomized double-blind, placebo-controlled design, participants will either consume creatine (CM), a placebo (PL), or no supplement (CON). CM and PL groups will be assigned a HIRT protocol, and the CON will do no training.

Conditions

  • Perimenopause

Interventions

DIETARY_SUPPLEMENT

Creatine Monohydrate

20 gram loading of creatine monohdyrate for 5 days, followed by 5 grams per day for 6 weeks

DIETARY_SUPPLEMENT

Placebo

20 grams daily of non-caloric placebo + 5 grams daily non-caloric placebo for 6 weeks

Sponsors & Collaborators

  • University of North Carolina, Chapel Hill

    lead OTHER

Principal Investigators

  • Abbie Smith-Ryan, PhD · University of North Carollina at Chapel Hill

Study Design

Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
DOUBLE
Model
PARALLEL

Eligibility

Min Age
38 Years
Max Age
60 Years
Sex
FEMALE
Healthy Volunteers
No

Timeline & Regulatory

Start
2025-06-02
Primary Completion
2025-12-15
Completion
2025-12-15

Countries

  • United States

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07027800 on ClinicalTrials.gov