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Effects of Resistance Training Intensity on Cardiovascular Parameters of Hypertensive Women

NCT06538454 · Status: RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 24

Last updated 2024-08-05

No results posted yet for this study

Summary

The goal of this clinical trial is to understand about the effects of resistance training (RT) intensity on cardiovascular parameters in postmenopausal women with systemic arterial hypertension (SAH). The main research questions are:

* Does the intensity of RT impact blood pressure (BP) in postmenopausal women with SAH?
* How does RT intensity affect heart rate (HR) and their variability (HRV), endothelial function (EF), and nitric oxide (NO) biomarker synthesis in this population?
* What are the effects of RT intensity on affectivity and rate of perceived exertion (RPE)?

Researchers will compare two different intensities of RT (60% of the load for 1 repetition maximum \[1RM\] and 80% of 1RM) to determine their effects on the mentioned cardiovascular and perceptual parameters.

Participants will:

In the acute experiment:

* Perform the same RT session in a crossover design, training with 60% of 1RM in one condition and 80% of 1RM in another condition
* Have BP, HR, and HRV measured before, immediately after, and for one hour post-session
* Report affectivity before each session and at the end, along with RPE

In the chronic experiment:

* Be randomized into two groups: one training with 60% of 1RM and the other with 80% of 1RM
* Undergo a 10-week intervention period with evaluations before, during, and after the intervention
* Have BP, HR, affective responses, and RPE measured at multiple time points
* Have EF, HRV, and salivary concentrations of NO biomarkers assessed before and after the intervention

Conditions

Interventions

BEHAVIORAL

Resistance training

The exercises will be the same in both stages: squat, bench press, stiff, rowing, hip thrust and shoulder press. Futhermore, the rest interval (2 minutes) and the exercise order (alterning upper and lower limbs) also will be the same in the stages. In the chronic experiment, the resistance training will be carried for 10 weeks with 2 weekly sessions in alternate days. The sets in both groups will be carried close to muscle failure. The difference between groups is the intensity, who reflects the repetition zone. The 80%1RM group will be perform 8-10 repetitions per set, while the 60%1RM group will be perform 18-20 repetitions.

Sponsors & Collaborators

  • University of Sao Paulo

    lead OTHER

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Model
PARALLEL

Eligibility

Min Age
50 Years
Max Age
65 Years
Sex
FEMALE
Healthy Volunteers
No

Timeline & Regulatory

Start
2024-07-23
Primary Completion
2024-09-30
Completion
2025-09-30

Countries

  • Brazil

Study Locations

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Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06538454 on ClinicalTrials.gov