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The Effect of Exercise on Myokine Production in Aging Persons

NCT05571709 · Status: UNKNOWN · Phase: NA · Type: INTERVENTIONAL · Enrollment: 20

Last updated 2023-03-31

No results posted yet for this study

Summary

The incidence of age-related diseases, such as cancer and cardiovascular diseases, rapidly rises. These days, age-related diseases cause the majority of all healthcare expenses. During ageing senescent cells secrete a range of harmful inflammatory signals, which leads to chronic inflammation (inflamm-aging) and accelerates aging throughout the rest of the body. Interestingly, people who regularly exercise show less signs of inflamm-aging compared to people with a sedentary lifestyle. Molecules secreted by skeletal muscles, called myokines, may play an important role. However, the underlying molecular mechanisms remain unknown. This pilot study aims to investigate if an acute bout of resistance training is an appropriate tool to induce an increase in the release of muscle derived myokines in aged persons.

Conditions

  • Aging
  • Exercise

Interventions

OTHER

Exercise training

Resistance training of the lower limbs

BEHAVIORAL

Questionnaire

Physical activity questionnaire

PROCEDURE

Percutaneous muscle biopsy

Muscle biopsy of the vastus lateralis (m. quadriceps)

PROCEDURE

Blood sample

Venous blood sample

Sponsors & Collaborators

  • Hasselt University

    lead OTHER

Principal Investigators

  • Chiel Hex, MD. · University of Hasselt

Study Design

Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
SINGLE
Model
PARALLEL

Eligibility

Min Age
65 Years
Max Age
85 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2022-09-15
Primary Completion
2023-10-15
Completion
2023-12-31

Countries

  • Belgium

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05571709 on ClinicalTrials.gov