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Assessing the Impact of Age, and a Short-term High-intensity Interval Training (HIIT) on Skeletal Muscle Mass and Mitochondrial Activity

NCT05934760 · Status: ACTIVE_NOT_RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 32

Last updated 2023-11-30

No results posted yet for this study

Summary

The goal of this interventional study is to learn about the role of mitochondrial function in healthy aging, and then go on and assess the role of a home-based exercise program on the changes seen. The main question\[s\] it aims to answer are:

* What alterations in skeletal muscle mitochondrial function are seen in healthy aging?
* Can a short-term exercise program alter these alterations seen?

The older participants will be invited to take part in a home-based 4 week exercise intervention involving either:

* High intensity interval training
* Resistance based training (resistance bands will be provided) Researchers will compare the two exercise groups to see if it alters mitochondrial function.

Conditions

Interventions

OTHER

High intensity interval training (HIIT)

Each HIIT session last 15 minutes. Participants will be asked to measure their own heart rate during their rest periods and provided with an estimated max heart rate which they should be aiming to achieve within the final 2 exercises. Participants will be provided with a logbook to record the heart rate achieved in each exercise. The regimen will include: * 2 min warm-up: jogging on the spot * Each of the following exercises performed for 60seconds, interspaced by 90 seconds rest * Star jumps * Standing squats * On-the-spot sprints * Standing squats * Star jumps * 2 min cool-down: jogging on the spot

OTHER

Resistance based training (RET)

Each RET session lasts an estimated 20minutes. Participants will be provided with a set of resistance bands to provide resistance to their workout, and a logbook to record the number of repetitions and band used. Each session will include: * 2 min warm-up jogging on the spot * 2 sets of 12-15 repetitions of: * Squats * Hip flexion * Hip extension * Hip abduction * Seated row * Bench press * Lateral raises * 2 min jogging on the spot cooldown. Each exercise will be separated by 1-minute rest, with participants encouraged to workout to mild fatigue on their final repetition in each set. If able to perform more than the allocated maximum of 15 repetitions prior to fatigue, then participants will be informed to increase the resistance by using a tougher resistance band.

Sponsors & Collaborators

  • University of Nottingham

    lead OTHER

Study Design

Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
NONE
Model
PARALLEL

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2019-12-17
Primary Completion
2023-12-30
Completion
2024-03-30

Countries

  • United Kingdom

Study Locations

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Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05934760 on ClinicalTrials.gov