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Effect of Meat and Egg on TMAO in Plasma and Urine in Subjects with and Metabolic Subjects

NCT06660251 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 33

Last updated 2024-10-28

No results posted yet for this study

Summary

The purpose of this clinical trial is to investigate in subjects with and without metabolic syndrome how meals of choline- and carnitine-rich foods (eggs and meat) affect the trimethylamine-N-oxide (TMAO) concentration in blood and urine in relation to the gut microbiota composition.

In response to the subjects´ gut microbiota, the concentrations of TMAO in the plasma and urine of subjects with and without metabolic syndrome (MetS) after ingesting choline- and carnitine-rich foods will be compared.

On two occasions, participants will receive after overnight fasting meatballs (170 g) or three hard-boiled eggs. Blood will be collected before ingestion and over 6 hours after test food consumption.

Conditions

  • Metabolic Syndrome X

Interventions

OTHER

Egg intervention

Oral administration of three hard-boiled eggs to be ingested within 15 minutes on one occasion.

OTHER

Meatball intervention

Oral intervention with 170 g meatballs to be ingested within 15 minutes on one occasion.

Sponsors & Collaborators

  • Umeå University

    collaborator OTHER

  • Linnaeus University

    lead OTHER

Principal Investigators

  • Mohammed E Hefni, Assoc Prof · Linnaeus University

Study Design

Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
NONE
Model
CROSSOVER

Eligibility

Min Age
18 Years
Max Age
75 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2020-02-07
Primary Completion
2023-05-05
Completion
2024-05-05

Countries

  • Sweden

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06660251 on ClinicalTrials.gov