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Effects of Choline From Eggs vs. Supplements on the Generation of TMAO in Humans

NCT03039023 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 86

Last updated 2025-11-04

Study results available
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Summary

The investigators are interested in learning more about choline, a nutrient required by the body. The body does make some choline, but it does not make enough to support health and the rest must be acquired through diet. Eggs, and especially egg yolks, are a major dietary source of choline. Choline can also be given as a dietary supplement. Ingestion of choline supplements has been linked to an increased concentration of a compound called TMAO (trimethylamine N-oxide). Elevated TMAO levels have been linked to higher heart disease risk. With this study, the investigators hope to learn whether there is a difference in the way your body responds to the ingestion of a choline supplement versus the choline found within eggs.

Conditions

  • Cardiovascular Risk Factor

Interventions

DIETARY_SUPPLEMENT

Choline Bitartrate

500mg choline bitartrate tablets

OTHER

Pre-cooked, pre-peeled whole hardboiled eggs

Obtained from a commercial source.

OTHER

Egg whites from pre-cooked, pre-peeled hardboiled eggs

Egg whites from pre-cooked, pre-peeled hardboiled eggs. The yolks are removed and discarded.

DIETARY_SUPPLEMENT

Phosphatidylcholine capsules

420 mg phosphatidylcholine capsules obtained from a commercial source.

Sponsors & Collaborators

  • The Cleveland Clinic

    lead OTHER

Principal Investigators

  • W. H. Wilson Tang, MD · The Cleveland Clinic

Study Design

Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
NONE
Model
PARALLEL

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2016-09-02
Primary Completion
2018-04-10
Completion
2020-09-03

Countries

  • United States

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03039023 on ClinicalTrials.gov