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Brain Responses to Short-Chain Fatty Acid Intervention

NCT06546683 · Status: NOT_YET_RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 32

Last updated 2024-08-09

No results posted yet for this study

Summary

A randomized, triple-blind, placebo-controlled study on the effect of colon-delivered short-chain fatty acids (SCFAs) on neural responses to stress and neuroepigenetics.

Conditions

  • Stress
  • Healthy Volunteers

Interventions

OTHER

Short-Chain Fatty Acids

Colon-delivery capsules of Short-Chain Fatty Acids will be administered in a ratio of 60:20:20, thus 150 mmol of acetate, 50 mmol of propionate and 50 mmol of butyrate equivalent to 20g of fibers, once daily, one week

OTHER

Placebo

Microcrystalline Cellulose will be used as placebo, one daily, one week

Sponsors & Collaborators

  • Universitaire Ziekenhuizen KU Leuven

    lead OTHER

Principal Investigators

  • Lukas Van Oudenhove, MD, PhD · KU Leuven

  • Annalena Fuchs, MSc · KU Leuven

  • Kristin Verbeke, Pharm, PhD · KU Leuven

  • Boushra Dalile, PhD · KU Leuven

Study Design

Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
TRIPLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
45 Years
Sex
MALE
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2024-09-30
Primary Completion
2026-12-31
Completion
2026-12-31

Countries

  • Belgium

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06546683 on ClinicalTrials.gov