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The Role of Short Chain Fatty Acids in Microbiota-gut-brain Axis

NCT03688854 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 66

Last updated 2018-10-02

No results posted yet for this study

Summary

The role of short chain fatty acids (SCFA) in the microbiota-gut-brain axis is examined in a sample of healthy volunteers. SCFA are the major products of bacterial fermentation of dietary fiber in the colon, and are hypothesised to mediate the bidrectional communication between the gut and the residing microbiota on the one hand, and the central nervous system on the other hand. We perform a 1-week intervention with SCFA and measure their effects on a range of affective outcomes in healthy male volunteers.

Conditions

  • Emotions
  • Stress
  • Fear

Interventions

DIETARY_SUPPLEMENT

SCFA mixture

Intracolonic administration

Sponsors & Collaborators

  • KU Leuven

    lead OTHER

Principal Investigators

  • Kristin Verbeke, Prof · KU Leuven

Study Design

Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
SINGLE
Model
PARALLEL

Eligibility

Min Age
20 Years
Max Age
40 Years
Sex
MALE
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2018-01-04
Primary Completion
2018-09-15
Completion
2018-09-15

Countries

  • Belgium

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03688854 on ClinicalTrials.gov